What is PGT
The only way to determine if an embryo is predicted to be affected with a genetic condition or chromosomal disorder prior to achieving pregnancy.
Preimplantation Genetic Testing (PGT) is performed in conjunction with an In Vitro Fertilization (IVF) cycle and can significantly reduce the chances of having a baby with a specific genetic condition or chromosomal abnormality. There are various types of PGT available, depending on the needs of the individuals.
Reliable Information for Family Planning
Reproductive Genetic Innovations offers state-of-the-art technologies to test embryos for Aneuploidies, Structural Rearrangements, Human Leukocyte Antigen and many different Monogenic (Single Gene) Disorders.
Testing can determine if an embryo contains the normal number of chromosomes or abnormality (which often causes birth defects and intellectual disabilities), reduces the chance of failed implantation or an early miscarriage, or whether an embryo is predicted to be affected with a genetic condition prior to achieving pregnancy. Some of the most common testable conditions can be found below. For our full list of testable single-gene disorders, CLICK HERE.
- Beta Thalassemia
- Fanconi Anemia
- Cystic Fibrosis
- Muscular Dystrophy
- Sickle-Cell Disease
- Huntington's Disease
- Tay-Sachs Disease
- Hyper IgM syndromes
- Down Syndrome
- Edwards Syndrome
- Turner Syndrome
and our team
Preimplantation Genetic Testing for Aneuploidy (PGT-A)
RGI is a recognized leader in the field of assisted reproductive technologies and has performed Preimplantation Genetic Testing (PGT) for thousands of families all over the world.
PGT-A determines if an embryo contains the normal number of chromosomes prior to pregnancy, transfer of which can optimize the success of an In Vitro Fertilization (IVF) cycle and reduce the chance of miscarriage.Getting started
Preimplantation Genetic Testing for Monogenic / Single Gene Defects (PGT-M)
PGT-M detects genetic conditions prior to pregnancy, including autosomal dominant, recessive, X-linked, and de novo conditions, which can help at-risk couples have children free of their family’s genetic diseases.
PGT-M allows for the selection of embryos free of a specific genetic disorder while avoiding the difficult decision about the outcome of a pregnancy following abnormal prenatal test results. RGI tests for some of the rarest conditions, offering customized test set-ups not available at other labs.Get started
Preimplantation Genetic Testing for Structural Rearrangements (PGT-SR)
PGT-SR identifies structural chromosomal abnormalities caused by rearrangements, including translocations, inversions, deletions and duplications, prior to achievement of a pregnancy.
PGT-SR allows for a viable pregnancy, reducing or avoiding the chance of a failed implantation, miscarriage and/or the birth of a child with congenital anomalies, resulting from an unbalanced chromosome translocation.Get started
Preimplantation Genetic Testing Human Leukocyte Antigen (PGT-HLA)
PGT-HLA identifies embryos that are HLA compatible with a child who is in need of a bone marrow or cord blood transplant used to treat a sibling affected with certain blood disorders.
PGT-HLA is requested by couples where a previous child is in need of a bone marrow or cord blood transplant due to a genetic disorder. In planning future pregnancy, not only is it desired to have a child without the disorder, but an HLA-compatible child whose umbilical cord blood can be used for stem cell transplantation, to provide normally functioning bone marrow.Get started
Pioneers in Preimplantation Genetic Testing
RGI is an internationally recognized leader in the field of assisted reproductive technologies and has performed Preimplantation Genetic Testing for thousands of families all over the world.
With over 30 years of experience in the field, we have helped to facilitate the birth of more than 10,000 healthy babies. Our PGT and IVF labs are where our expert staff of scientists, doctors, and genetic counselors were among the first in the world to successfully implement innovative techniques for families interested in genetic testing on their embryos as a part of the IVF process.
RGI boasts one of the largest catalogs of testable gene mutations and disorders (650+ Single Gene Disorders and counting) in the world. Our proprietary techniques and customized testing processes are significantly more comprehensive with 98% accuracy.
RGI performed the world’s first PGT for single gene disorder by polar body sampling
Developed PGT for chromosomal aneuploidies using polar body analysis
Introduced Multiplex Nested PCR analysis, remaining the main tool for avoiding PGT misdiagnosis
Performed the world’s first PGT for HLA matching
Published “PGD Atlas” First Edition; Second Edition – 2005; 3rd Edition -2014
Developed approaches to PGT for conditions caused by De Novo mutations
Performed the world’s first case of PGT for Prion disorder
Introduced the first systematic application of combined PGT for monogenic and chromosomal disorders
Helped facilitate the birth of over 10,000 healthy babies