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How Can Preimplantation Genetic Testing Help Me

Preimplantation Genetic Testing (PGT) is performed in conjunction with an In Vitro Fertilization (IVF) cycle and is used to select embryos with the highest likelihood of resulting in a healthy on-going pregnancy. Various types of PGT are available, depending on the needs of the individuals.

Indications for PGT

Advanced Maternal Age
Testing Previously Frozen Embryos
Maximizing a Transfer of Successful Donor Oocytes
Prior Pregnancy of Child with a Chromosomal Abnormality
Recurrent Pregnancy Loss
Repeated IVF Failures
Patient Desire to Determine Sex
Need for HLA matching
History of hereditary disorder
Carrier status of genetically inheritable disease
Our Tests

Preimplantation Genetic Testing for Aneuploidy (PGT-A)

RGI is a recognized leader in the field of assisted reproductive technologies, and has performed Preimplantation Genetic Testing (PGT) for thousands of families all over the world.

PGT-A determines if an embryo contains the normal number of chromosomes prior to pregnancy, transfer of which can optimize the success of an In Vitro Fertilization (IVF) cycle and reduce the chance of miscarriage.

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Preimplantation Genetic Testing for Monogenic / Single Gene Conditions (PGT-M)

PGT-M detects genetic conditions prior to pregnancy, including autosomal dominant, recessive, X-linked, and de novo conditions, which can help at-risk couples have children free of their family’s genetic diseases.

PGT-M allows for the selection of embryos, free of genetic disorder while avoiding the difficult decision about the outcome of a pregnancy following abnormal prenatal test results. RGI tests for rare conditions, offering specific test set-ups not available at other labs.

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Preimplantation Genetic Testing for Structural Rearrangements (PGT-SR)

PGT-SR identifies structural chromosomal abnormalities caused by rearrangements, including translocations, inversions, deletions and duplications, prior to achievement of a pregnancy.

PGT-SR allows for a viable pregnancy, reducing or avoiding the chance of a failed implantation, miscarriage and/or the birth of a child with congenital anomalies, resulting from an unbalanced chromosome translocation.

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Preimplantation Genetic Testing Human Leukocyte Antigen (PGT-HLA)

PGT-HLA identifies embryos that are HLA compatible with a child who is in need of a bone marrow or cord blood transplant used to treat a sibling affected with certain blood disorders.

PGT-HLA is requested by couples where a previous child is in need of a bone marrow or cord blood transplant due to a genetic disorder. In planning future pregnancy, not only is it desired to have a child without the disorder, but an HLA-compatible child whose umbilical cord blood can be used for stem cell transplantation, to provide normally functioning bone marrow.

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Understanding IVF & PGT

In Vitro Fertilization is the most common method of assisted reproductive technology and is an essential part of the process that includes Preimplantation Genetic Testing or PGT (formerly known as PGD or PGS).

An IVF cycle begins with injections to the woman in order to stimulate her ovaries to produce multiple eggs (oocytes). Once the eggs are retrieved from the woman, they are fertilized by a single sperm injection in a controlled lab environment. These fertilized eggs, now called embryos, grow into a desired state of development where they can be biopsied and tested for specific inherited genetic disease or chromosomal abnormalities. Healthy embryos can be identified and recommended for implantation back into the female patient improving the chances of having a successful and healthy pregnancy.

Preimplantation Genetic Testing (PGT) 

Preimplantation Genetic Testing (PGT) is the only way to determine if an embryo is predicted to be affected with a genetic condition or chromosomal disorder prior to achieving pregnancy.

Reproductive Genetic Innovations offer state-of-the-art technologies to test embryos for many different conditions, including Aneuploidies (PGT-A) and Single Gene Defects (PGT-M), Structural Rearrangements(PGT-SR) and Human Leukocyte Antigen matching (PGT-HLA). Our tests help select the embryo(s) not having a chromosomal abnormality or single gene disorder known to be at increased risk

PGT does not replace prenatal testing, such as chorionic villus sampling or amniocentesis, which are the standard of care during a pregnancy.

Reasons for PGT Testing

Improves Pregnancy Rates by 20%
Reduces Chance of Miscarriage by 3X
50% of Pregnancy Losses are Caused by Chromosome Abnormalities
Aneuploidy is the most common cause of miscarriage and implantation failure
Nearly half of all in-vitro embryos have chromosomal abnormalities
Aneuploidy rates increase with maternal age from approximately 30% at age 35, to 85% at age 42

Preimplantation Genetic Testing for Monogenic Disorders (PGT-M)


Preimplantation Genetic Testing for Aneuploidy

At Reproductive Genetic Innovations, it is our goal to provide families with the best chance at having a healthy baby. We work with Reproductive Endocrinologists and other IVF clinicians for optimal patient care, and to support you and your family along the way.

How & When is PGT Performed?

PGT is performed by sampling the developing embryo at different time points in conjunction with an IVF cycle. RGI customizes the testing strategy to obtain the most accurate diagnosis for your embryos. Your IVF physician will determine which testing option is most appropriate for you.

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What Counseling Is Available?

Our genetic counselors are available to discuss testing options with you and guide you through every step of the process.

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Does RGI Have an Online Patient Portal?

RGI’s robust patient and provider portal combines comprehensive clinical functionality for electronic medical record with advanced navigability for end-users with collaboration features and analytics that create a dynamic, intuitive and powerful anywhere-anytime solution.

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How Does RGI Provide Billing Support?

We provide a tailored approach to billing. Following your initial consultation, our staff will work with you to simplify the process — from benefit verification to claim submission, we will provide the necessary documents and help establish a payment process should your policy not provide coverage for PGT services.

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What is the PGT Process?

Before RGI receives your biopsy samples, our expert PGT Technologists will develop a testing plan that will be based on your individual needs in concert with your doctor’s recommendation.

  • Counseling + Testing Plan Counseling + Testing Plan
  • PGT Set-Up PGT Set-Up
  • IVF + Embryo Biopsy IVF + Embryo Biopsy
  • PGT Testing PGT Testing
  •  Result + Embryo Selection

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How Do We Get Started?

Discover the best chance for a healthy pregnancy and peace of mind with RGI.

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