PGT-M

PGT-M is a genetic testing technique designed to identify if there is a single-gene disorder(s) in embryos created through in vitro fertilization (IVF). These disorders, which include conditions such as cystic fibrosis, sickle cell anemia, and Huntington’s disease, are usually caused by mutations in a single gene. By testing embryos for these genetic abnormalities before implantation, couples can select and transfer only those embryos that are free from the targeted disorder (genetic variant), avoiding the risk of passing it on to their children.

Preimplantation Genetic Testing for Human Leukocyte Antigens (PGT-HLA) provides patients with an option not only to avoid an inherited risk when combined with single gene testing (PGT-M), but also to establish a pregnancy with an exact HLA match to benefit an affected family member.

Deoxyribonucleic acid (or DNA) is the chemical novel of you.  A little less than half of your story comes from a paternal inheritance (for some people this […]

As the title states, non-disclosure involves keeping the at-risk individual’s status for a condition such as Huntington disease, for example, unknown. How can this be done, you may ask?

Throughout your pre-implantation testing journey, you might hear terms like PGT-A, PGT-M, PGT-SR, PGT-HLA, NGS, PCR, etc. All these letters can get pretty confusing if you aren’t sure what they mean, so let’s break it down. 

Screening is now pan-ethnic, and uses DNA platforms. Couples of mixed ethnicities are screened without regard to specific ethnicity. Over 400 disorders can be screened, identifying approximately 2% at-risk couples.

If you or your partner have a family history of heart attack or sudden death at a young age, family members with pacemakers or internal cardiac defibrillators, arrhythmia, and cardiac surgery you may consider carrier screening. Carrier Screening will determine whether PGT should be considered as is an option during your family planning. With Preimplantation Genetic Testing (PGT), there is a way to prevent your children from being carriers of the same gene mutation.